Differential expression of genes controlling lymphocyte differentiation and migration in two distinct endotypes of type 1 diabetes
Authors' conclusion
The results provide evidence that histologically defined type 1 diabetes endotypes differ in their immunopathology and identify inflammatory pathways specifically involved in disease developing at a young age, essential for a better understanding of disease heterogeneity.
Study context
- Population
- Pancreas samples from young people with recent-onset T1D, characterised by endotype, and controls without diabetes
- Participants
- 29 vs 7
- Comparison
- T1D cases (by endotype) vs controls without diabetes, and between the two T1D endotypes
- T1D casesn = 29
- Controlsn = 7reference
- Outcome
- Expression levels of 750 genes associated with autoimmune inflammation
Methodological detailsmultiplexed gene expression analysis, fixed, paraffin-embedded pancreas tissue
- Multiplexed gene expression analysis
- Fixed, paraffin-embedded pancreas tissue
Main finding
As reported in the abstract
Differential gene expression
Inflammation-associated genes, including INS, significantly under-expressed in both endotypes
10
Genes more highly expressed in both endotypes
48
Distinct set of genes (lymphocyte development, activation and migration) uniquely overexpressed in pancreas of people developing diabetes at younger age
13
Original publication
Differential expression of genes controlling lymphocyte differentiation and migration in two distinct endotypes of type 1 diabetes. Diabet Med. Published 11 June 2023. doi:10.
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