Recovery of intracellular glucose uptake in T cells during partial remission of type 1 diabetes
Authors' conclusion
Intracellular glucose uptake in T cells was specifically decreased during partial remission in type 1 diabetes and may be related to PD-1 upregulation, which may be involved in the down-modulation of immune responses during partial remission. This study suggests that altered immune metabolism could be a target for interventions at the point of diagnosis of type 1 diabetes.
Study context
- Population
- Participants with new-onset T1D or T1D in partial remission, compared with healthy individuals and T2D; new-onset participants followed up as remitters or non-remitters
- Exposure
- T cell intracellular glucose and fatty acid uptake: new-onset T1D vs T1D in partial remission, vs healthy individuals and T2D
- Outcome
- Intracellular glucose uptake by T cells
Methodological detailsfollow-up component
- Follow-up component
Main finding
As reported in the abstract
- Intracellular glucose uptake by T cells decreased significantly in partial remission vs new-onset T1D
- During follow-up, uptake decreased during partial remission and rebounded after remission; dynamic only in remitters, not non-remitters
Observational data: associations, not effects.
Further findings
Glucose uptake in T cell subsets
- Changes found in CD4+ and CD8+ subsets, incl. Th17, Th1, CD8+ naive T cells (Tn) and CD8+ Temra
PD-1 expression
- Glucose uptake in CD8+ T cells negatively related to PD-1 expression
Intracellular fatty acid metabolism
- Not different between new-onset participants and those in partial remission
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Recovery of intracellular glucose uptake in T cells during partial remission of type 1 diabetes. Diabetologia. Published 10 June 2023. doi:10.
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