Single‐cell transcriptional profiling reveals cellular senescence and inflammatory persistence as key features of type 1 diabetes partial remission
Authors' conclusion
These findings reveal previously unrecognized features of immune dysregulation during PR and provide potential therapeutic targets for T1D treatment.
Study context
- Population
- Healthy controls, newly diagnosed T1D patients and T1D patients in partial remission; peripheral blood mononuclear cells
- Comparison
- Healthy controls vs newly diagnosed T1D vs T1D in partial remission
- Outcome
- Monocyte heterogeneity and stage-specific alterations
Methodological detailssingle-cell RNA sequencing of PBMCs
- Single-cell RNA sequencing of PBMCs
Main finding
As reported in the abstract
- Five distinct monocyte subsets with unique molecular signatures and stage-specific alterations
- Partial remission (PR): persistent inflammatory responses, with expansion of IL1B+ monocytes and sustained activation of TNF and IL6-STAT3 signalling
- PR: significant reduction of HDAC9+ populations
- PR: marked accumulation of senescent cells across monocyte subsets (elevated senescence-associated secretory phenotype scores, increased P21 expression)
- PR: altered developmental dynamics on trajectory analysis, with distinct classical and non-classical monocyte branches
- Sustained activation of EGR1 and NFκB signalling throughout disease progression, particularly during PR
Original publication
Single‐cell transcriptional profiling reveals cellular senescence and inflammatory persistence as key features of type 1 diabetes partial remission. Diabetes Obes Metab. Published 4 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →