Type 1 diabetes

Reduction of Postprandial Glucose Excursions in Adults, Adolescents, and Children with Type 1 Diabetes Using Ultra-Rapid Lispro Insulin and Control-IQ+ Technology

Diabetes Technol TherPublished Comparative study

Main finding · Postprandial glucoseResult — go to the resultAdjusted mean difference −11 mg/dL

Authors' conclusion

In conclusion, compared with insulin lispro, the use of URLi with Control-IQ+ technology modestly improved postprandial glucose excursions with the greatest amount of improvement for breakfast and in those with insulin resistance.

Study context

Population
Adults, adolescents and children with T1D using Control-IQ+ technology
Participants
176 adults
Comparison
Ultra-rapid lispro vs insulin lispro, with Control-IQ+ technology
Outcome
Postprandial glucose
Follow-up
60 min

Main finding

As reported in the abstract

Adjusted mean difference

−11 mg/dL

P < 0.001

By group

Further findings

OutcomeAdjusted mean difference (mg/dL)P value
Mean glucose excursion−4P = 0.001

mg/dL

Mean glucose excursion — AMD after breakfast
−9
Mean glucose excursion — AMD after lunch
−2
Mean glucose excursion — AMD after dinner
−2

Mean glucose excursion by insulin-to-carbohydrate ratio (ICR)

mg/dL

AMD, ICR <5 g/U
−11
AMD, ICR 5-15 g/U
−2
AMD, ICR >15 g/U
1

Original publication

Reduction of Postprandial Glucose Excursions in Adults, Adolescents, and Children with Type 1 Diabetes Using Ultra-Rapid Lispro Insulin and Control-IQ+ Technology. Diabetes Technol Ther. Published 2 April 2025. doi:10.1089/dia.2025.0077

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