Ultra rapid lispro showed greater reduction in postprandial glucose versus Humalog in children, adolescents and adults with type 1 diabetes mellitus
Authors' conclusion
URLi showed an accelerated insulin lispro absorption and greater postprandial glucose reduction compared with Humalog in children, adolescents and adults with T1D.
Study context
- Population
- Children (6–11 years), adolescents (12–17 years) and adults (18–64 years) with T1D; 13 children, 14 adolescents, 15 adults13 children · 14 adolescents · 15 adults
- Comparison
- Ultra rapid lispro vs Humalog
Methodological detailstwo-period, subject- and investigator-blind, single-dose
- Two-period
- Subject- and investigator-blind
- Single-dose
Primary result
As reported in the abstract
- Onset of appearance faster with ultra rapid lispro (URLi) vs Humalog, all age groups (all p < .01)
- 4-5 min
- Early 50% tmax reduced with URLi vs Humalog, all age groups (all p < .01)
- 7-13 min
- Exposure in first 15 min increased with URLi vs Humalog, all age groups (all p < .01)
- 3.5-6.5-fold
- Exposure after 3 h decreased with URLi vs Humalog (p = .02)
- 37-58%
- Duration reduced with URLi vs Humalog, children (p = .006)
- 56 min
- Duration reduced with URLi vs Humalog, adolescents (p = .022)
- 36 min
- 1-h postprandial glucose reduced with URLi vs Humalog, children (p = .008)
- 42 mg/dl
- 1-h postprandial glucose reduced with URLi vs Humalog, adolescents (p = .195)
- 19 mg/dl
- 1-h postprandial glucose reduced with URLi vs Humalog, adults (p = .018)
- 34 mg/dl
- Glucose excursion over 5-h test meal reduced with URLi vs Humalog, children
- 16%
- Glucose excursion over 5-h test meal reduced with URLi vs Humalog, adolescents
- 9%
Safety
Tolerability
- URLi was well tolerated in all age groups
Original publication
Ultra rapid lispro showed greater reduction in postprandial glucose versus Humalog in children, adolescents and adults with type 1 diabetes mellitus. Diabetes Obes Metab. Published 3 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →