Comparison of Serum Creatinine– and Cystatin C–Based Estimated Glomerular Filtration Rate (eGFR) at Baseline and Their Prediction of Incident Moderate Albuminuria in Individuals With Type 1 Diabetes
Authors' conclusion
These findings suggest SCysC may facilitate early identification of individuals at risk for albuminuria.
Study context
- Population
- FinnDiane Study participants with T1D without kidney failure, with serum creatinine (SCr) and serum cystatin C (SCysC) data; 51.8% men; median age 36.6 (IQR 27.7–46.4) years; median DM duration 19.5 (IQR 10.9–29.2) years
- Participants
- 3,769 participants
- Exposure
- Cystatin C–based eGFR vs creatinine-based eGFR
- Outcome
- Concordance between SCr- and SCysC-based eGFR
- Follow-up
- Baseline
Main finding
As reported in the abstract
eGFRcys–eGFRcr concordance/discordance
- Mean absolute eGFRdiff
- 14.0 ± 12.2 mL/min/1.73 m²
Observational data: associations, not effects.
Further findings
Factors contributing to discordance
- Sex, albuminuria status, smoking, retinal laser photocoagulation, HbA1c, HDL cholesterol, hs-CRP and insulin dose per kg contributed to discordance
Incident moderate albuminuria
- SCysC and eGFRcys associated with incident moderate albuminuria; EGFR of creatinine (eGFRcr) not
Original publication
Comparison of Serum Creatinine– and Cystatin C–Based eGFR at Baseline and Their Prediction of Incident Moderate Albuminuria in Individuals With Type 1 Diabetes. Diabetes Care. Published 2 April 2025. doi:10.
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