Elevated triglyceride-glucose index is a risk factor for cardiovascular events in adults with type 1 diabetes: a cohort study
Authors' conclusion
A higher TyG index was significantly associated with an increased risk of CVD and all-cause mortality in patients with T1DM.
Study context
- Population
- Patients with T1D enrolled 2009–2015; Triglyceride-glucose (TyG) quartile cut-offs 8.46, 9.03 and 9.60
- Participants
- 14,543 patients
- Exposure
- TyG index quartiles
- Outcome
- Incidence of cardiovascular disease (CVD), including MI, ischemic stroke and HF
- Follow-up
- Median 7.52 years
Main finding
As reported in the abstract
Composite CVD
Estimate (95% CI)
Q4vs Q1
aHR 1.80(1.62–2.00)
Q4vs Q1
aHR (MI) 1.70(1.38–2.10)
Q4vs Q1
aHR (ischemic stroke) 2.11(1.78–2.50)
Q4vs Q1
aHR (HF) 1.65(1.45–1.88)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| All-cause mortalityQ4vs Q1 | 1.60 (1.41–1.81) | |
| 0.512Adjusted hazard ratio (log scale) |
Cardiometabolic risk factors
- Highest TyG quartile had a higher burden of obesity, hypertension, dyslipidemia and lower HDL-C
Original publication
Elevated triglyceride-glucose index is a risk factor for cardiovascular events in adults with type 1 diabetes: a cohort study. Cardiovasc Diabetol. Published 2 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →