Elevated triglyceride‐glucose index is associated with increased risk of chronic kidney disease and end‐stage renal disease in type 1 diabetes: Nationwide cohort study
Authors' conclusion
The TyG index may serve as a valuable clinical indicator to identify individuals with type 1 diabetes at high risk for developing incident CKD and ESRD.
Study context
- Population
- Adults with T1D, Korean National Health Insurance Service database
- Participants
- 14,782 adults
- Exposure
- Quartiles of baseline triglyceride-glucose (TyG) index
- Outcome
- Incident CKD and end-stage renal disease (ESRD)
- Follow-up
- Median 7.04 years
Methodological detailsCox proportional hazards models, multivariable adjustment, competing-risk analysis
- Cox proportional hazards models
- Multivariable adjustment
- Competing-risk analysis
Main finding
As reported in the abstract
Risk of chronic kidney disease (CKD) (fold)
2.15
95% CI 1.87–2.48P for trend < 0.001
Q4
Risk of end-stage renal disease (ESRD) (fold)
2.90
95% CI 2.25–3.75P for trend < 0.001
Q4
Observational data: associations, not effects.
Further findings
Competing-risk analysis including all-cause mortality
- Associations remained significant
5-year CKD stage distribution
- Higher TyG quartiles associated with progressively worsening distribution of 5-year CKD stages
Original publication
Elevated triglyceride‐glucose index is associated with increased risk of chronic kidney disease and end‐stage renal disease in type 1 diabetes: Nationwide cohort study. Diabetes Obes Metab. Published 7 January 2026. doi:10.
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