Association of baseline and trajectory of triglyceride-glucose index with the incidence of cardiovascular autonomic neuropathy in type 2 diabetes mellitus
Primary result · Incidence of CAN by baseline TyG indexResult — go to the resultOdds ratio 1.29 95% CI 1.03–1.62Authors' conclusion
Increased baseline levels and long-term trajectory of TyG index are associated with an increased incidence of CAN. Intensive glycemic therapy might influence the association between the trajectory of TyG index and the chance of developing CAN.
Study context
- Population
- Individuals with T2D in the ACCORD trial
- Comparison
- Triglyceride-glucose (TyG) index quartiles and TyG trajectory classes
- Class 1n = 431reference
- Class 2n = 798
- Class 3n = 293
- Primary endpoint
- Incidence of CAN
Methodological detailsmultivariate logistic regression, restricted cubic splines, trajectory analysis, Cox proportional hazards regression
- Multivariate logistic regression
- Restricted cubic splines
- Trajectory analysis
- Cox proportional hazards regression
Primary result
Incidence of CAN by baseline TyG index
Odds ratio
1.29
95% CI 1.03–1.62
P = 0.027
Q4vs Q1
OR 1.29 (95% CI 1.03–1.62); P = 0.027
As reported in the abstract
Further findings
CAN risk by TyG trajectory · 7-year follow-up — Class 1 vs Class 3 · Kaplan-Meier, differences across trajectories
P < 0.001
TyG index for predicting cardiovascular autonomic neuropathy (CAN)
- AUC
- 0.636 (95% CI 0.620-0.651; P < 0.001)
- Cut-off value
- 0.208
CAN risk by TyG trajectory · 7-year follow-up
- Class 3 had greater incidence of CAN vs class 1 after full covariate adjustment (Cox)
- Subgroup analysis: no significant effect modification
Intensive vs standard glycemia: trajectory and CAN risk
- In intensive glycemia group, class 2 had reduced and class 3 increased CAN risk vs standard glycemia group
Original publication
Association of baseline and trajectory of triglyceride-glucose index with the incidence of cardiovascular autonomic neuropathy in type 2 diabetes mellitus. Cardiovasc Diabetol. Published 7 February 2025. doi:10.
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