Fibroblast growth factor 23 predicts incident diabetic kidney disease: A 4.6‐year prospective study
Main finding · Incident DKD per baseline FGF23Result — go to the resultOdds ratio 1.290 95% CI 1.063–1.565Authors' conclusion
Serum FGF23 level increased at early stages of DKD, and it was an independent predictor of incident DKD, suggesting its potential for early identification of individuals at risk.
Study context
- Population
- Individuals with diabetes at baseline from a community-based cohort completing a 4.6-year follow-up surveywith diabetes at baseline
- Participants
- 1,614 individuals
- Exposure
- Baseline serum FGF23 levels and incident diabetic kidney disease (DKD)
- Outcome
- Incident DKD
- Follow-up
- 4.6-year follow-up
Methodological detailscommunity-based
- Community-based
Main finding
Incident DKD per baseline FGF23 · 4.6 years
Odds ratio
1.290
95% CI 1.063–1.565
Baseline FGF23
OR 1.290 (95% CI 1.063–1.565)
Per baseline FGF23, as printed
As reported in the abstract
- Individuals developing incident DKD
- 198
Observational data: associations, not effects.
Further findings
Association by subgroup
- Association especially in individuals with BMI <24 kg/m², HbA1c ≥7% and diabetes duration <5 years
Baseline FGF23 across DKD stages
- FGF23 elevated early in DKD and increased gradually with progressive DKD stages
- P < 0.05
- No statistical changes in serum calcium and phosphorus
DKD risk prediction
- FGF23 models yielded increments vs traditional DKD risk factors
- P < 0.05
Original publication
Fibroblast growth factor 23 predicts incident diabetic kidney disease: A 4.6‐year prospective study. Diabetes Obes Metab. Published 3 February 2025. doi:10.
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