Risk of cardiovascular disease, death, and renal progression in diabetes according to albuminuria and estimated glomerular filtration rate
Authors' conclusion
Non-albuminuria DKD accounts for more than half of DKD cases with low eGFR in Chinese diabetes patients. Diabetes patients with albuminuria are at higher risks of developing clinical outcomes and warrant early intervention, as well as patients with non-albuminuria DKD with age < 65 years.
Study context
- Population
- Adults with T2D from 20 community sites across mainland China, followed 2011–2016
- Participants
- 36,509 adults
- Exposure
- Diabetic kidney disease (DKD) subtypes by albuminuria and eGFR vs no DKD
- Outcome
- MACE, renal outcomes (CKD progression) and all-cause mortality
Methodological detailsmulticentre, community-based
- Multicentre
- Community-based
Main finding
As reported in the abstract
MACE, mortality and CKD progression by DKD subtype
Alb-/eGFR+ vs Alb-/eGFR-Hazard ratio (95% CI)
MACE
1.42(1.08–1.88)
Mortality
1.42(1.04–1.92)
CKD progression; not significantly increased
0.97(0.60–1.57)
Observational data: associations, not effects.
Further findings
Prevalence of normal UACR (non-albuminuria DKD) among participants with reduced eGFR
- Normal UACR among participants with diabetes and reduced eGFR
- 53.5%
MACE and mortality in non-albuminuria DKD, by age subgroup
- Associations of non-albuminuria DKD with MACE and mortality more evident in those aged <65 years
Original publication
Risk of cardiovascular disease, death, and renal progression in diabetes according to albuminuria and estimated glomerular filtration rate. Diabetes Metab. Published 12 January 2023. doi:10.
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