Prospective randomised placebo-controlled trial assessing the efficacy of silver dressings to enhance healing of acute diabetes-related foot ulcers
Primary result · Ulcers healedResult — go to the resultOdds ratio 0.92 CI 0.26–3.22Authors' conclusion
In individuals with acute DFUs without osteomyelitis or tendon on view, Acticoat silver dressings did not improve wound healing or reduce need for antibiotics compared with non-silver dressings.
Study context
- Population
- Consecutive individuals with acute DFU (<6 weeks' duration) without osteomyelitis or tendon on view, tertiary multidisciplinary diabetic foot servicerandomised 1:1
- Participants
- 63 vs 55
- Comparison
- Acticoat silver dressing vs non-silver dressing, each with standard care
- Silvern = 63
- Controln = 55reference
- Primary endpoint
- Proportion of ulcers healed
- Follow-up
- 12 weeks
Methodological detailsopen-label, stratified randomisation (peripheral arterial disease, infection), single tertiary multidisciplinary diabetic foot service
- Open-label
- Stratified randomisation (peripheral arterial disease, infection)
- Single tertiary multidisciplinary diabetic foot service
Primary result
Ulcers healed
Odds ratio
0.92
CI 0.26–3.22
P = 0.53
By group
Silvervs Control
OR 0.92 (CI 0.26–3.22); P = 0.53
As reported in the abstract
Secondary outcomes
- No difference in time to healing, progression to osteomyelitis, need for amputation, or duration of or need for antibiotic treatment
Original publication
Prospective randomised placebo-controlled trial assessing the efficacy of silver dressings to enhance healing of acute diabetes-related foot ulcers. Diabetologia. Published 11 January 2023. doi:10.
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