Continuous intrafemoral artery infusion of urokinase improves diabetic foot ulcers healing and decreases cardiovascular events in a long-term follow-up study
Primary result · Complete ulcer healingResult — go to the resultHazard ratio 3.42 95% CI 2.35–4.98Authors' conclusion
Continuous intrafemoral thrombolysis therapy has a better therapeutic efficacy to improve DFUs and decrease cardiovascular events.
Study context
- Population
- Patients with diabetic foot ulcer (DFU)
- Participants
- 195 patients
- Comparison
- Continuous intrafemoral thrombolysis vs conventional therapy
- Primary endpoint
- Ulcer closure rate
- Follow-up
- 6.5-year follow-up
Methodological detailssingle-center, parallel, Average follow-up 6.5 years
- Single-center
- Parallel
- Average follow-up 6.5 years
Primary result
Complete ulcer healing
Hazard ratio
3.42
95% CI 2.35–4.98
P < 0.0001
Continuous intrafemoral thrombolysisvs Conventional therapy
HR 3.42 (95% CI 2.35–4.98); P < 0.0001
As reported in the abstract
Secondary outcomes
Complete ulcer closure · first 1 month of intervention
Improved ulcer · first 1 month of intervention
Unchanged or impaired ulcer · first 1 month of intervention
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| CVD events (secondary outcome) · 6.5-year follow-upLower incidence with continuous intrafemoral thrombolysis | 0.50 (0.34–0.74) | P < 0.0001 | |
| 0.20.5125Hazard ratio (log scale) |
Cardiovascular death
- Intrafemoral thrombolysis therapy decreased the incidence of cardiovascular death
- HR 0.42 (95%CI 0.20 to 0.89, p=0.0241)
Local skin oxygenation, peripheral neuropathy and glycolipid metabolic profiles
- Improved with continuous intrafemoral thrombolysis vs conventional therapy
- P < 0.05
Original publication
Continuous intrafemoral artery infusion of urokinase improves diabetic foot ulcers healing and decreases cardiovascular events in a long-term follow-up study. BMJ Open Diabetes Res Care. Published 12 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →