Validation of an international classification of disease, tenth revision, clinical modification ( ICD‐10‐CM ) algorithm in identifying severe hypoglycaemia events for real‐world studies
Authors' conclusion
We translated an ICD-9-CM hypoglycaemia algorithm to an ICD-10-CM version and found its performance was modest. The performance of the algorithm improved by removing poor performing codes at the trade-off of missing very few severe hypoglycaemia events. The algorithm has the potential to be used to identify severe hypoglycaemia in real-world studies of antidiabetic drugs.
Study context
- Population
- Medicare patients with DM with linked electronic health record (EHR) data, University of North Carolina Health System642 candidate events
- Comparison
- ICD-10-CM algorithm vs Refined algorithm
- Outcome
- PPV of the algorithm for severe hypoglycaemia confirmed by EHR review
Methodological detailsvalidation study, EHR review as reference
- Validation study
- EHR review as reference
Performance
As reported in the abstract
PPV of the ICD-10-CM hypoglycaemia algorithm for severe hypoglycaemia (confirmed by EHR review)
Candidate severe hypoglycaemia events identified
642
Confirmed as true severe hypoglycaemia events
455
PPV
0.709 (0.672, 0.744) (95% CI)
Further findings
Agreement between EHR reviewers
- Cohen's κ
- 0.93 (0.89, 0.97)
Original publication
Validation of an international classification of disease, tenth revision, clinical modification ( ICD‐10‐CM ) algorithm in identifying severe hypoglycaemia events for real‐world studies. Diabetes Obes Metab. Published 11 January 2024. doi:10.
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