Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced estimated myocardial energetic efficiency in subjects with different degrees of glucose tolerance
Authors' conclusion
These data suggest that an impairment in insulin-stimulated myocardial glucose metabolism is an independent contributor of depressed myocardial MEEi in subjects without history of CHD.
Study context
- Population
- Individuals without history of coronary heart disease having different degrees of glucose tolerance
- Participants
- 57 individuals
- Exposure
- Lowest vs highest tertile of insulin-stimulated myocardial MrGlu
- Outcome
- Relationship between insulin-stimulated myocardial MrGlu (dynamic 18F-FDG positron emission tomography (PET) with euglycemic-hyperinsulinemic clamp) and myocardial MEEi
Methodological detailstertiles of myocardial MrGlu, adjusted for age, gender and BMI
- Tertiles of myocardial MrGlu
- Adjusted for age, gender and BMI
Main finding
As reported in the abstract
Myocardial MEEi
P = 0.02
- Multivariate regression including several CV risk factors: only variable significantly associated with mechano-energetic efficiency (MEEi) was myocardial MrGlu
- β 0.346; P = 0.01
Observational data: associations, not effects.
Further findings
MVO2 · increase in I tertile; adjusted for age, gender and BMI
P < 0.0001
Univariate correlations of myocardial MrGlu
- Positively correlated with whole-body glucose disposal; negatively correlated with waist circumference, FPG, HbA1c and MVO2
Original publication
Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced estimated myocardial energetic efficiency in subjects with different degrees of glucose tolerance. Cardiovasc Diabetol. Published 9 January 2023. doi:10.
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