Raised levels of Interleukin‐8 and myeloperoxidase in patients with recent onset type 1 diabetes
Authors' conclusion
Our findings support an elevation of IL-8 in both pancreatic tissue and serum in recent-onset T1D and suggest that higher IL-8 levels may be associated with poorer glycemic control. Further studies are needed to clarify the mechanistic role of IL-8 in T1D pathogenesis.
Study context
- Population
- Individuals with recent-onset T1D and controls; pancreatic samples from a diabetes biobank
- Participants
- 42 vs 11
- Comparison
- Recent-onset T1D vs controls
- T1Dn = 42
- Controlsn = 11reference
- Outcome
- Pancreatic IL-8 and IL-8 receptor expression; serum IL-8 and myeloperoxidase (MPO)
Methodological detailsbiobank pancreatic samples, serum ELISA
- Biobank pancreatic samples
- Serum ELISA
Main finding
As reported in the abstract
- IL-8 and IL-8 receptor gene expression significantly increased in pancreas of T1D vs controls
- Serum IL-8 significantly increased in patients vs controls
- T1D vs Controls: P = 0.0349
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| HbA1c and blood glucose in T1D by IL-8 >62 vs ≤62 pg/mLIL-8 >62 pg/mL vs IL-8 ≤62 pg/mL | P = 0.015 |
| HbA1c and blood glucose in T1D by IL-8 >62 vs ≤62 pg/mLIL-8 >62 pg/mL vs IL-8 ≤62 pg/mL · higher with IL-8 >62: 360 [283-488.5] vs 243.5 [197.5-314.5] | P = 0.019 |
- HbA1c and blood glucose in T1D by IL-8 >62 vs ≤62 pg/mL: higher with IL-8 >62: 100 [79.40-122.8] vs 79.50 [52.25-96.25]; HbA1c (%) 11.30 [9.52-13.38] vs 9.45 [6.95-10.93]
Original publication
Raised levels of Interleukin‐8 and myeloperoxidase in patients with recent onset type 1 diabetes. Diabetes Obes Metab. Published 1 September 2025. doi:10.
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