Mauriac Syndrome in Sudanese Children: An Old Syndrome Still Existing in Resource‐Limited Countries
Authors' conclusion
Despite many efforts that have been made to achieve better glycemic control in children with T1DM, MS still exists in our setting. Though liver biopsy is the gold standard for diagnosis, being invasive, the diagnosis could be made conservatively, based on clinical features and response to treatment. The condition can be reversed with good metabolic control.
Study context
- Population
- Sudanese children and adolescents with Mauriac syndrome due to inadequate diabetes control (T1D or neonatal diabetes), single centre
- Participants
- 37 children
- Outcome
- Magnitude, clinical features, management and outcome of Mauriac syndrome
Methodological detailshospital-based, medical record review, Patients were re-educated, management intensified, then followed up
- Hospital-based
- Medical record review
- Patients were re-educated, management intensified, then followed up
Main finding
As reported in the abstract
Outcome after re-education and intensified management
Improved (decrease in liver size with or without increased growth velocity)
21
56.8%
Static condition
7
18.9%
Lost to follow-up
8
21.6%
Died
1
2.7%
Observational data: associations, not effects.
Further findings
Patient characteristics
- Male
- 59.5%
- Neonatal diabetes (others T1D)
- 5.4%
- Median age at mauriac syndrome (MS) diagnosis
- 12 years
- Diagnosis based solely on clinical findings (prolonged poor glycemic control, short stature, hepatomegaly)
Associated complications
- Nephropathy, the most common associated complication; some at a very young age
- 33.3%
Original publication
Mauriac Syndrome in Sudanese Children: An Old Syndrome Still Existing in Resource‐Limited Countries. Pediatr Diabetes. Published 26 August 2025. doi:10.
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