An MRI study of pancreatic atrophy in children with type 1 diabetes: Heterogeneity, disease duration effects, and progression prediction models
Authors' conclusion
Children with T1D exhibit altered pancreatic size and morphology, with heterogeneity in pancreatic atrophy. Pancreatic atrophy progressed at follow-up compared to baseline, and disease duration exacerbated these pancreatic alterations. An integrated model can effectively predict pancreatic atrophy progression.
Study context
- Population
- Children with T1D and control children35 T1D with follow-up MRI
- Participants
- 90 vs 82
- Exposure
- Children with T1D vs control children
- T1Dn = 90
- Controln = 82reference
- Outcome
- Pancreatic MRI size and morphology
Methodological detailsMRI, case-control comparison, longitudinal follow-up subset, linear mixed-effect models
- MRI
- Case-control comparison
- Longitudinal follow-up subset
- Linear mixed-effect models
Main finding
As reported in the abstract
- T1D vs controls: lower pancreatic volume, pancreatic volume index (PVI), pancreatic head, body and tail diameters, pancreatic surface area and margin regularity score; higher pancreatic surface area-to-volume ratio
Observational data: associations, not effects.
Further findings
Disease duration subgroups (≥3 vs <3 years)
- PVI and pancreatic surface area reduced with duration ≥3 years vs <3 years
Glycaemic control subgroups
- Pancreatic head diameter and surface area lower with poor vs good glycaemic control
Age at diagnosis subgroups (<8 vs ≥8 years)
- Pancreatic surface area decreased with age at diagnosis <8 years vs ≥8 years
Longitudinal change in T1D
- PVI and pancreatic head diameter progressively decreased with disease duration
Prediction of pancreatic atrophy progression
- AUC, combined clinical and MR parametric model
- 0.736
Original publication
An MRI study of pancreatic atrophy in children with type 1 diabetes: Heterogeneity, disease duration effects, and progression prediction models. Diabetes Obes Metab. Published 22 August 2025. doi:10.
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