Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes
Authors' conclusion
Individuals with T1D exhibit a hypercoagulable hemostatic profile compared with healthy controls and exercise-related hypoglycemia may increase the susceptibility to thrombosis via both procoagulant and antifibrinolytic effects.
Study context
- Population
- Men with T1D and matched healthy controlscrossover in T1D
- Comparison
- T1D vs matched healthy controls; Hypo-exercise vs Hypo-rest within T1D
- T1Dn = 15
- Outcome
- Thrombelastography hemostatic profile
Methodological detailsrandomized, crossover, euglycemic-hypoglycemic clamp, matched healthy controls
- Randomized
- Crossover
- Euglycemic-hypoglycemic clamp
- Matched healthy controls
Main finding
As reported in the abstract
Hypo-exercise: increased clot strength (MA), mean difference from baseline
2.77 mm
95% CI 2.04–3.51
Hypo-exercise: decreased fibrinolysis (LY-30) from baseline
−0.45 percentage point
−0.60 to −0.29
Hypo-rest: increased functional fibrinogen (MA-FF) from baseline
0.74 mm
0.13–1.36
Hypo-rest: increased fibrinolysis (LY-30) from baseline
0.54 percentage point
0.11–0.98
Original publication
Hemostatic Effects of Exercise-related Hypoglycemia in Male Persons With Type 1 Diabetes. J Clin Endocrinol Metab. Published 20 April 2024. doi:10.
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