Exercise‐related hypoglycaemia induces QTc ‐interval prolongation in individuals with type 1 diabetes
Authors' conclusion
We found that both exercise-related hypoglycaemia and hypoglycaemia induced at rest can cause QTc-interval prolongation and Tpe-interval prolongation in people with type 1 diabetes. Thus, both scenarios may increase susceptibility to ventricular arrhythmias.
Study context
- Population
- Men with T1Dcrossover
- Participants
- 15 men
- Comparison
- Exercise-related hypoglycaemia vs hypoglycaemia induced at rest
Methodological detailshyperinsulinaemic euglycaemic-hypoglycaemic clamp, Holter-ECG monitoring
- Hyperinsulinaemic euglycaemic-hypoglycaemic clamp
- Holter-ECG monitoring
Primary result
As reported in the abstract
QTc and Tpe interval during hypoglycaemic phase (PG <3.0 mmol/L)
- QTc and Tpe interval increased significantly from baseline during hypoglycaemia, with no significant difference between test days
- Accompanied by increased plasma adrenaline and decreased plasma potassium on both days
Further findings
ΔQTc and ΔTpe interval in recovery phase
- ΔQTc interval longer during Clamp-rest vs Clamp-exercise
- ΔTpe interval similar on the two test days
Original publication
Exercise‐related hypoglycaemia induces QTc ‐interval prolongation in individuals with type 1 diabetes. Diabetes Obes Metab. Published 19 January 2023. doi:10.
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