The protective effect of high-intensity interval exercise compared with continuous moderate exercise on glycaemic decline is more pronounced in the postabsorptive vs postprandial state in adults with type 1 diabetes: a randomised crossover trial
Authors' conclusion
In adults with type 1 diabetes, HIIE provides a greater training stimulus than iso-mechanical CONT while limiting the decline in capillary blood glucose during exercise and reducing exposure to clinically relevant hypoglycaemia during late recovery. Importantly, the protective effect of HIIE vs CONT against exercise-induced decrease in glucose levels was more pronounced in the PA than in the PP state, with HIIE performed in the PA state showing the smallest decreases.
Study context
- Population
- Physically active adults with T1D for >1 year, aged 18–55 years; nine female; mean ± SD age 33.4 ± 9.4 years; Lille Universitycrossover, 4 sessions
- Participants
- 20 adults
- Comparison
- High-intensity interval exercise (HIIE) vs CONT in the postabsorptive and postprandial states
- HIIE-PAn = 20
- HIIE-PPn = 20
- CONT-PAn = 20reference
- CONT-PPn = 20reference
- Primary endpoint
- Change in capillary glucose during exercise
- Follow-up
- During 25 min cycling session
Methodological detailsiso-mechanical
- Iso-mechanical
Primary result
As reported in the abstract
HIIE-PA
−0.72
mean · SD 1.71 · mmol/l
CONT-PA
−1.73
mean · SD 1.48 · mmol/l
HIIE-PP
−2.33
mean · SD 1.61 · mmol/l
CONT-PP
−2.61
mean · SD 1.27 · mmol/l
Postabsorptive (PA) state vs PP state: P = 0.003 · HIIE vs CONT: P = 0.038 · HIIE vs CONT in PA vs HIIE vs CONT in PP: P = 0.001
Further findings
| Outcome | P value |
|---|---|
| Physiological response (oxygen consumption, heart rate, blood lactate, perceived exertion) · during exerciseHIIE vs CONT · higher with HIIE | P < 0.05 |
Physiological response (oxygen consumption, heart rate, blood lactate, perceived exertion) · during exercise
- HIIE did not reduce exercise enjoyment
Time at <3.0 mmol/l · 24 h post-exercise
- Less time at <3.0 mmol/l after HIIE than CONT (adjusted for carbohydrate intake and insulin doses), despite lower dietary glycaemic load
Original publication
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