Pre‐Exercise Galactose or Lactose Reduces Glycaemic Excursions During Exercise in Adults With Type 1 Diabetes: A Randomised, Double‐Blind, Crossover Trial
Authors' conclusion
Pre-exercise galactose and lactose provide more stable glycaemic responses than dextrose and reduce time below range compared with placebo.
Study context
- Population
- Adults with T1D completing four 60-min cycling sessionscrossover
- Participants
- 14 adults
- Comparison
- Pre-exercise galactose or lactose vs dextrose and vs placebo
- Dextrose (DEX)n = 14
- Lactose (LAC)n = 14
- Galactose (GAL)n = 14
- Placebo (PLA)n = 14reference
- Primary endpoint
- Time to hypoglycaemia
Methodological detailsdouble-blind, 4-condition crossover
- Double-blind
- 4-condition crossover
Primary result
As reported in the abstract
Hypoglycaemic events / time to hypoglycaemia
Dextrose
0
events
Lactose
2
events
Galactose
1
events
Placebo
4
events
P = 0.42
- Seven hypoglycaemic events in total
- 7
Secondary outcomes
| Outcome | Dextrose (DEX) | Lactose (LAC) | Galactose (GAL) | Placebo (PLA) | P value |
|---|---|---|---|---|---|
| Time in rangeDextrose (DEX) vs Lactose (LAC), Galactose (GAL), Placebo (PLA) · lower for dextrose | 48% (CI 40–57) | 70% (CI 62–78) | 71% (CI 63–79) | 86% (CI 80–91) | all p ≤ 0.01 |
| Time below rangeDextrose (DEX), Lactose (LAC), Galactose (GAL) vs Placebo (PLA) · lower vs placebo | 0% (CI 0–3) | 1% (CI 0–5) | 1% (CI 0–5) | 8% (CI 4–14) | all p < 0.05 |
- Time above range · Dextrose (DEX), Lactose (LAC), Galactose (GAL) vs Placebo (PLA) · higher vs placebo
- all p < 0.01
- Time in range: 95% CI
- Time below range: 95% CI
- Time above range: 95% CI
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Pre‐Exercise Galactose or Lactose Reduces Glycaemic Excursions During Exercise in Adults With Type 1 Diabetes: A Randomised, Double‐Blind, Crossover Trial. Diabetes Obes Metab. Published 9 June 2026. doi:10.
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