Combined intake of caffeine and low‐dose glucose to reduce exercise‐related hypoglycaemia in individuals with type 1 diabetes on ultra‐long‐acting insulin degludec: A randomized, controlled, double‐blind, cross‐over trial
Primary result · Time to hypoglycaemiaResult — go to the resultRisk reduction 85.7%Authors' conclusion
Pre-exercise caffeine ingestion combined with a low dose of glucose reduced exercise-related hypoglycaemia compared with control while avoiding hyperglycaemia.
Study context
- Population
- Adults with T1D using ultra-long-acting insulin degludec; three aerobic exercise sessions (max 75 min)cross-over
- Participants
- 16 adults
- Comparison
- Caffeine + glucose vs glucose alone vs aspartame alone before exercise
- Primary endpoint
- Time to hypoglycaemia
Methodological detailsdouble-blind, cross-over
- Double-blind
- Cross-over
Primary result
As reported in the abstract
Risk reduction
85.7%
P = 0.044
- Significant effect of condition on time to hypoglycaemia
- χ2 = 7.674, p = .0216
Further findings
Glucose levels during exercise
Peak plasma glucose during exercise — CAF vs GLU · did not differ
P = 0.80
- Glucose levels during exercise — CAF increased glucose levels vs GLU and ASP
- p < .001
- Peak plasma glucose during exercise — CAF and GLU higher than ASP
- p < .001
- Glucose difference CAF vs GLU, last 15 min of exercise · largest difference during last 15 min
- P = 0.002
- Perceived exertion · CAF vs GLU · lower with CAF
- P = 0.023
Original publication
Combined intake of caffeine and low‐dose glucose to reduce exercise‐related hypoglycaemia in individuals with type 1 diabetes on ultra‐long‐acting insulin degludec: A randomized, controlled, double‐blind, cross‐over trial. Diabetes Obes Metab. Published 1 April 2024. doi:10.
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