Excess Mortality in an Inception Cohort of Childhood Diabetes Diagnosed 1990–2010
Authors' conclusion
Compared to the general population, higher risk of mortality in people with type 1 diabetes was associated with female sex and living in area of socioeconomic disadvantage. Education about minimizing risk-taking behaviors should be communicated to young adults with type 1 diabetes.
Study context
- Population
- Children diagnosed with T1D at age < 16 in New South Wales, Australia, 1990–2010 (Australasian Paediatric Endocrinology Group diabetes register), linked to National Death Index up to 31/12/2022157 died
- Participants
- 5,417 children
- Exposure
- Childhood-onset T1D vs Australian general population
- Outcome
- All-cause mortality vs general population (SMR)
- Follow-up
- Up to 31/12/2022
Methodological detailsregister-linked, indirect standardization
- Register-linked
- Indirect standardization
Main finding
As reported in the abstract
All-cause mortality
All-cause mortality
1.37/1,000 person years
Overall SMR
2.83
95% CI 2.40, 3.33
SMR in females vs males
4.18 vs. 2.19
Observational data: associations, not effects.
Further findings
Risk factors for mortality
- Living in most disadvantaged areas
- aHR 1.81 (1.05, 3.11)
- Living in a rural area: not associated with increased mortality risk
- Multivariable Cox regression
Causes of death
- Acute diabetes complications, incl. DKA
- 26%
- Accident/misadventure
- 21%
- Chronic diabetes complications
- 15%
- Alcohol and/or drug use contributed
- 17%
Original publication
Excess Mortality in an Inception Cohort of Childhood Diabetes Diagnosed 1990–2010. Pediatr Diabetes. Published 29 March 2024. doi:10.
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