Human Leukocyte Antigen (HLA) Class I Association With Autoimmune Diabetes in Chinese People: Distinct Implications in Classic Type 1 Diabetes and Latent Autoimmune Diabetes in Adults (LADA)
Authors' conclusion
The attenuated HLA Class I susceptibility to LADA was indicative of a less deleterious immunogenetic nature compared with classic T1D. These autoimmune diabetes-related Class I variants might serve as additional markers in future screening among Chinese people.
Study context
- Population
- Chinese people with classic T1D or LADA and normal controls
- Participants
- 1,067 / 1,062 / 1,107
- Comparison
- Classic T1D vs LADA vs normal controls
- Classic T1Dn = 1,067
- LADAn = 1,062
- Normal controlsn = 1,107reference
- Outcome
- Association of HLA Class I alleles with risk and clinical features of classic T1D and LADA
Methodological detailsnext-generation sequencing
- Next-generation sequencing
Main finding
As reported in the abstract
Alleles shared by classic T1D and LADA: protective A*02:07 and B*46:01; susceptible B*54:01 and C*08:01
4 alleles
Class I alleles conferring risk only for classic T1D (A*24:02, B*15:02, B*15:18, B*39:01, B*40:06, B*48:01, C*07:02)
7 alleles
Observational data: associations, not effects.
Further findings
Class I associations with clinical features of classic T1D
- Positive rate of protein tyrosine phosphatase autoantibody and zinc transporter 8 autoantibody: A*24:02
- C-peptide levels: A*24:02
- Age at diagnosis: B*46:01, C*01:02, B*15:02, C*07:02, C*08:01
Class I associations with clinical features of LADA
- Detrimental effect of C*08:01 on C-peptide in LADA; no other Class I associations with LADA clinical characteristics
Risk prediction models
- Adding Class I alleles refined the DR-DQ-only risk model in classic T1D; overall predictive value of the LADA model with Class I and II was relatively low
Original publication
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