Is low‐dose glucagon needed and effective in preventing fasted exercise‐induced hypoglycaemia in type 1 diabetes treated with the MiniMed 780G , an automated insulin delivery system?
Authors' conclusion
Adults with T1D treated with the MiniMed™ 780G can perform spontaneous fasted moderate-intensity exercise without hypoglycaemia. Therefore, glucagon was not needed for prevention of hypoglycaemia in such situations.
Study context
- Population
- Adults with T1D on MiniMed 780G automated insulin delivery (AID); age 50 [42–67] years, diabetes duration 22 [14–44] years, HbA1c 55 [47–69] mmol/mol; 45 min fasted moderate-intensity (≈60% V̇O2peak) cycling then 1 h restfour female
- Participants
- 10 adults
- Comparison
- SC glucagon 150 μg before fasted exercise vs no glucagon
- Primary endpoint
- Plasma glucose (PG) response during spontaneous fasted morning moderate-intensity exercise
Methodological detailsproof-of-concept, two-period
- Proof-of-concept
- Two-period
Primary result
As reported in the abstract
PG response during exercise
TIR (3.9-10.0 mmol/L) on both visits
100%
Further findings
Endogenous glucoregulatory hormones
- No differences between visits
Safety
- No hypoglycaemia (<3.9 mmol/L) occurred in either arm (GLUC or NO-GLUC)
Original publication
Is low‐dose glucagon needed and effective in preventing fasted exercise‐induced hypoglycaemia in type 1 diabetes treated with the MiniMed 780G , an automated insulin delivery system? Diabetes Obes Metab. Published 27 November 2024. doi:10.
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