Automated Insulin Delivery Around Exercise in Adults with Type 1 Diabetes: A Pilot Randomized Controlled Study
Authors' conclusion
In adults using an AID system and undertaking postprandial exercise, a strategy involving both bolus insulin dose reduction and exercise announcement 90 min before commencing the activity may be most effective in minimizing dysglycemia.
Study context
- Population
- Adults with T1D (HbA1c 8.3% ± 0.6%) using an automated insulin delivery (AID) system (MiniMed 780G), performing 45 min moderate-intensity continuous exercise 90 min after a carbohydrate-based mealcrossover
- Participants
- 10 adults
- Comparison
- Bolus reduction with exercise announcement 90 or 45 min before exercise vs full bolus with announcement at exercise onset, with AID
Methodological detailsthree-period, crossover, pilot, In instances of hypoglycemia, plasma glucose (PG) data were carried forward for the remainder of the visit
- Three-period
- Crossover
- Pilot
- In instances of hypoglycemia, PG data were carried forward for the remainder of the visit
Primary result
As reported in the abstract
TBR (<3.9 mmol/L), venous PG · 3 h collection period
P = 0.029
Further findings
TIR (3.9-10 mmol/L) · 1 h postexercise — between AE90 and SE · across 3 strategies; higher TIR with AE90
P = 0.033
TBR (<3.9 mmol/L) · 1 h postexercise — between AE90 and SE · across 3 strategies; lower TBR with AE90
P = 0.041
Events
| Outcome | SE | AE90 | AE45 | ꭓ2 [2] | P value |
|---|---|---|---|---|---|
| Hypoglycemia during exerciseBetween SE and AE90 · across 3 strategies | 4 | 1 | 1 | 3.600 | P = 0.165 |
Original publication
Automated Insulin Delivery Around Exercise in Adults with Type 1 Diabetes: A Pilot Randomized Controlled Study. Diabetes Technol Ther. Published 8 May 2023. doi:10.
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