A Randomized Crossover Pilot Study Evaluating Glucose Control During Exercise Initiated 1 or 2 h After a Meal in Adults with Type 1 Diabetes Treated with an Automated Insulin Delivery System
Authors' conclusion
Premeal announcement combining meal bolus reduction and increased glucose target was effective and safe during 60 min of moderate-intensity aerobic exercise, whether exercise onset was 60 or 120 min following a meal.
Study context
- Population
- Adults with T1D using automated insulin delivery (AID) (A1c 7.9% ± 0.6%, age 53.5 ± 15.5 years, T1D duration 29.0 ± 16.0 years); AID target raised from 6 to 9 mmol/L and 33% meal bolus reduction6 females
- Participants
- 13 adults
- Comparison
- Exercise 60 min vs 120 min after a meal, with meal bolus reduction and increased AID glucose target
Primary result
As reported in the abstract
Mean change in plasma glucose (PG) · prebreakfast to postexercise
60EX
−0.8
mean · ± 2.4 · mmol/L
120EX
+0.3
mean · ± 2.3 · mmol/L
P = 0.082
Further findings
| Outcome | 60EX | 120EX | P value |
|---|---|---|---|
| PG time in range (3.9-10.0 mmol/L) · prebreakfast to postexerciseDid not differ | 63.4% ± 43.1% | 51.9% ± 29.7% | P = 0.219 |
| PG time above range (>10.0 mmol/L) · prebreakfast to postexerciseDid not differ | 36.3% ± 43.3% | 48.1% ± 29.7% | P = 0.211 |
| Glucose rise premeal to pre-exercise60EX attenuated glucose rise | +1.8 ± 2.1 mmol/L | +3.9 ± 2.1 mmol/L | P = 0.001 |
Safety
Hypoglycemic events (<3.9 mmol/L) · during the study
- Hypoglycemic events during the study
- 0
Original publication
A Randomized Crossover Pilot Study Evaluating Glucose Control During Exercise Initiated 1 or 2 h After a Meal in Adults with Type 1 Diabetes Treated with an Automated Insulin Delivery System. Diabetes Technol Ther. Published 6 December 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →