Trends in Incidence of Hospitalization for Hypoglycemia and Diabetic Ketoacidosis in Individuals With Type 1 or Type 2 Diabetes With and Without Severe Mental Illness in Denmark From 1996 to 2020: A Nationwide Study
Authors' conclusion
SMI is an important risk factor for acute diabetes complication and effective prevention is needed in this population, especially among the younger population and those with schizophrenia.
Study context
- Population
- Individuals with T1D or T2D in Denmark, nationwide registers 1996–2020; 8% had severe mental illness (SMI)
- Participants
- 433,609 individuals
- Exposure
- Diabetes with SMI vs without SMI
- Outcome
- Hospitalization for hypoglycemia and DKA (recurrent events)
Methodological detailsnationwide registers, Poisson regression
- Nationwide registers
- Poisson regression
Main finding
As reported in the abstract
First hypoglycemia event
Each group vs without SMIEstimate (95% CI)
SMI
IRR (T1D) 1.77(1.56–2.00)
SMI
IRR (T2D) 1.64(1.55–1.74)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| First DKA eventSMIvs Without SMI | IRR (T1D) 1.78 (95% CI 1.50–2.11) | |
| First DKA eventSMIvs Without SMI | IRR (T2D) 1.85 (95% CI 1.64–2.09) | |
| 0.512Ratio (log scale) |
Recurrent hypoglycemia in schizophrenia
- Individuals with schizophrenia particularly at risk for recurrent hypoglycemia events
IR differences by age and calendar year
- Except for diabetic ketoacidosis (DKA) in T2D, IR differences between SMI and no SMI highest in younger individuals (<50 years) but stable across calendar year
Original publication
Trends in Incidence of Hospitalization for Hypoglycemia and Diabetic Ketoacidosis in Individuals With Type 1 or Type 2 Diabetes With and Without Severe Mental Illness in Denmark From 1996 to 2020: A Nationwide Study. Diabetes Care. Published 19 April 2024. doi:10.
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