Adolescents and Young Adults with Type 1 Diabetes Present Changes in Arterial Compliance and Resistance and Increased Arterial Stiffness
Authors' conclusion
Our data confirm premature aging of the vascular system in adolescents and young adults with T1DM and extend our knowledge by showing important changes in central and peripheral hemodynamics indices.
Study context
- Population
- Adolescents and young adults with T1D and healthy controls, matched by age and sexmatched by age and sex
- Participants
- 90 adolescents
- Exposure
- T1D vs healthy controls
- T1DMn = 45
- CTRLn = 45reference
Methodological detailsobservational, matched by age and sex, Oscillometric brachial artery pressure assessment for noninvasive estimation of central arterial pressures
- Observational
- Matched by age and sex
- Oscillometric brachial artery pressure assessment for noninvasive estimation of central arterial pressures
Further findings
Peripheral arterial compliance
Central arterial compliance
Peripheral vascular resistance
Central vascular resistance
| Outcome | T1DM | CTRL |
|---|---|---|
| AIx@75 | 24.96% ± 8.88% | 20.16% ± 9.95% |
AIx@75
- AIx@75 significantly higher in T1DM vs CTRL
Peripheral arterial compliance
- Significantly lower in T1DM vs CTRL
Central arterial compliance
- Significantly lower in T1DM vs CTRL
Peripheral vascular resistance
- Significantly higher in T1DM vs CTRL
Central vascular resistance
- Significantly higher in T1DM vs CTRL
Weight and BMI
- Weight and BMI significantly higher in T1DM
Original publication
Adolescents and Young Adults with Type 1 Diabetes Present Changes in Arterial Compliance and Resistance and Increased Arterial Stiffness. Pediatr Diabetes. Published 17 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →