Associations Between Arterial Stiffness and Metabolic Target in Children and Adolescents With Type 1 Diabetes Treated in a Modern Setting
Authors' conclusion
Despite modern treatment technology and better overall metabolic control, children and adolescents with type 1 diabetes present with a high prevalence of elevated arterial stiffness. Higher arterial stiffness was associated with higher age and lower time-in-range, independent of other risk factors, including HbA1c.
Study context
- Population
- Children and adolescents with T1D, modern technology-based cohort, Pediatric Diabetes Departments across Eastern Denmark, May 2022–January 2024; median age 14.2 years, 82% on CSII
- Participants
- 127 children
- Outcome
- Prevalence of elevated arterial stiffness (cfPWV z-score over the 90th percentile)
Main finding
As reported in the abstract
Elevated arterial stiffness (cfPWV z-score >90th percentile)
Prevalence of elevated arterial stiffness
16%
Observational data: associations, not effects.
Further findings
Associations with carotid-femoral pulse-wave-velocity (cfPWV), adjusted linear regression
- Higher age: standardized β 0.38 (95% CI 0.27, 0.48); p < 0.001
- Lower TIR: standardized β −0.15 (95% CI (−0.26), (−0.03)); p < 0.011
- Adjusted for age, sex, diabetes duration, TIR, hemoglobin A1c (HbA1c), body mass index (BMI) z-score, LDL-C and mean arterial pressure (MAP)
Associations with cfPWV, unadjusted
- Higher cfPWV associated with longer diabetes duration, higher age, HbA1c, MAP and liver stiffness, and lower TIR and insulin sensitivity
Original publication
Associations Between Arterial Stiffness and Metabolic Target in Children and Adolescents With Type 1 Diabetes Treated in a Modern Setting. Pediatr Diabetes. Published 26 October 2024. doi:10.
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