Evaluation of the Steno Type 1 Risk Engine in predicting cardiovascular events in an ethnic mixed population of type 1 diabetes mellitus and its association with chronic microangiopathy complications
Authors' conclusion
ST1RE performed well in predicting CV events at 5 and 10 years of follow-up. Moreover, higher ST1RE scores were associated with the progression of microangiopathy complications in this genetically heterogeneous T1D population.
Study context
- Population
- Adults with T1D free of cardiovascular (CV) events at baseline, ethnically mixed population; median age 25 years (IQR 21–32), median T1D duration 13 years (IQR 9–18)
- Participants
- 435 adults
- Exposure
- High and moderate vs low ST1RE risk groups
- Outcome
- Performance of ST1RE in predicting CV events
- Follow-up
- 5 and 10 years
Methodological detailsprognostic model validation
- Prognostic model validation
Main finding
As reported in the abstract
CV events · median follow-up 9.2 years (IQR 6.0-10.7)
Hazard ratio (95% CI)P value
Highvs Low
52.02(18.60–145.51)
P < 0.001Moderatevs Low
8.66(2.90–25.80)
P < 0.001- Overall patients with a CV event
- 5.5%
- Estimated vs observed CV events at 5 years
- 3.4% vs. 3.5%; χ2 = 10.12, p = 0.899
- Estimated vs observed CV events at 10 years
- 6.8% vs. 9.9%; χ2 = 14.80, p = 0.676
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Progression of microangiopathies, high vs low ST1REHigh vs Low · greater with High | P = 0.008 |
| Progression of microangiopathies, high vs low ST1REHigh vs Low · greater with High | P < 0.001 |
| Progression of microangiopathies, high vs low ST1REHigh vs Low · greater with High | P = 0.021 |
| Progression of microangiopathies, high vs low ST1REHigh vs Low · greater with High | P = 0.008 |
Original publication
Evaluation of the Steno Type 1 Risk Engine in predicting cardiovascular events in an ethnic mixed population of type 1 diabetes mellitus and its association with chronic microangiopathy complications. Cardiovasc Diabetol. Published 22 October 2024. doi:10.
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