Association of Elevated Arterial Stiffness With Cardiac Target Organ Damage and Cardiac Autonomic Neuropathy in Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study
Authors' conclusion
AS is associated with cardiac changes in young adults with diabetes. CAN-induced AS does not appear to be an etiology for cardiac abnormalities in this cohort.
Study context
- Population
- Young adults with youth-onset diabetes from the SEARCH for Diabetes in Youth Study; mean age 23 years
- Participants
- 222 vs 177
- Exposure
- T1D vs T2D
- T1Dn = 222
- T2Dn = 177
- Outcome
- Association of arterial stiffness (AS) with cardiac target organ damage (echocardiographic structure and function)
Main finding
As reported in the abstract
Association of AS with cardiac changes, adjusted for CV risk factors (linear regression)
- Arterial stiffness (AS) associated with cardiac structure (left ventricular mass index)
- P < 0.0001
- AS associated with systolic function (ejection fraction)
- P = 0.03
- AS associated with diastolic function (transmitral E/A wave velocities ratio)
- P = 0.008
- AS associated with diastolic function (e'/a' waves)
- P = 0.02
Observational data: associations, not effects.
Further findings
Association between AS and cardiac autonomic neuropathy (CAN)
- Association between AS and CAN not significant when other important covariates were added
Difference by diabetes type
- Relationships mostly similar in T1D and T2D
Original publication
Association of Elevated Arterial Stiffness With Cardiac Target Organ Damage and Cardiac Autonomic Neuropathy in Young Adults With Diabetes: The SEARCH for Diabetes in Youth Study. Diabetes Care. Published 2 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →