Prevalence and incidence of cardiovascular and renal diseases in type 1 compared with type 2 diabetes: A nationwide French observational study of hospitalized patients
Authors' conclusion
Although the crude prevalent burden of CV diseases may be lower in T1DM than in T2DM, patients with T1DM may have a higher risk of incident MI, HF, all-cause death and CV death above 60 years of age, highlighting the need for improved prevention in this population.
Study context
- Population
- All adult patients hospitalized in French hospitals in 2013 with at least 5 years of follow-up, categorized by diabetes status2,033,239 person-years
- Participants
- 50,623 vs 425,207
- Exposure
- T1D vs T2D
- T1DMn = 50,623
- T2DMn = 425,207reference
- Outcome
- Prevalence and event rates of MI, HF, ischemic stroke, CKD, all-cause death and CV death
- Follow-up
- Median 5.3 years (IQR 2.8 - 5.8 years)
Methodological detailshospitalized patients, age stratification of 10-year intervals, age and sex-adjusted
- Hospitalized patients
- Age stratification of 10-year intervals
- Age and sex-adjusted
Main finding
As reported in the abstract
Incident events, age and sex-adjusted HR, T1DM vs T2DM
- -fold
- HR, myocardial infarction (MI) (above 60 years) 1.2
- -fold
- HR, heart failure (HF) (above 60 years) 1.4
- -fold higher in T1DM
- Risk of incident chronic kidney disease (CKD) (above 60 years) 2.4
- -fold higher in T1DM
- HR, all-cause death (after 60 years) 1.1
- -fold higher in T1DM
- Cardiovascular (CV) death risk (60–69 years) 1.15
Observational data: associations, not effects.
Further findings
Age and sex-adjusted prevalence
- Prevalence of CV diseases higher in T2DM for ages above 40 years
- Prevalence of CKD more common in T1DM between ages 18 and 70 years
Original publication
Prevalence and incidence of cardiovascular and renal diseases in type 1 compared with type 2 diabetes: A nationwide French observational study of hospitalized patients. Diabetes Metab. Published 1 February 2023. doi:10.
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