Associations of microvascular complications with all‐cause death in patients with diabetes and COVID ‐19: The CORONADO , Association of British Clinical Diabetologists (ABCD) COVID‐19 UK national audit and AMERICADO study groups
Authors' conclusion
Microvascular burden is associated with an increased risk of death in patients hospitalized for COVID-19.
Study context
- Population
- Patients with diabetes hospitalized for COVID-19: French CORONADO, UK ABCD COVID-19 audit and AMERICADO (New York area)3 studies
- Comparison
- Microvascular complications vs no microvascular complications
- Outcome
- All-cause death during hospital stay
- Follow-up
- During hospital stay
Methodological detailsmulticentre, nationwide (CORONADO, ABCD COVID-19 audit), New York area (AMERICADO), Microvascular status ascertained for 1314 (44.5%) of 2951 CORONADO, 1809 (53.4%) of 3387 ABCD and 7367 (79.0%) of 9327 AMERICADO participants; ≥1 complication: 1010, 1059 and 1800; free of complications: 304, 750 and 5567, respectively
- Multicentre
- Nationwide (CORONADO, ABCD COVID-19 audit)
- New York area (AMERICADO)
- Microvascular status ascertained for 1314 (44.5%) of 2951 CORONADO, 1809 (53.4%) of 3387 ABCD and 7367 (79.0%) of 9327 AMERICADO participants; ≥1 complication: 1010, 1059 and 1800; free of complications: 304, 750 and 5567, respectively
Pooled result
As reported in the abstract
All-cause death during hospital stay, meta-analysis of 3 studies
Each group vs free of complicationsEstimate (95% CI)
Microvascular complications
unadjusted OR 2.05(1.42–2.97)
Microvascular complications
OR adjusted for age and sex 1.62(1.19–2.119)
Microvascular complications
OR adjusted for age, sex, hypertension and CVD 1.50(1.12–2.02)
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| All-cause death during hospital stay, per study, adjusted for age, sex, hypertension and CVDMicrovascular complicationsvs Free of complications | adj OR (CORONADO) 2.57 (95% CI 1.69–3.92) | |
| All-cause death during hospital stay, per study, adjusted for age, sex, hypertension and CVDMicrovascular complicationsvs Free of complications | adj OR (ABCD COVID-19 audit) 1.22 (95% CI 1.00–1.52) | |
| All-cause death during hospital stay, per study, adjusted for age, sex, hypertension and CVDMicrovascular complicationsvs Free of complications | adj OR (AMERICADO) 1.33 (95% CI 1.15–1.53) | |
| 0.20.5125Ratio (log scale) |
All-cause death during hospital stay with isolated DKD, per study
- Isolated DKD, OR (CORONADO)
- 2.53 (95% CI 1.66-3.83)
- Isolated DKD, OR (ABCD COVID-19 audit)
- 1.24 (95% CI 1.00-1.56)
- Isolated DKD, OR (AMERICADO)
- 1.66 (95% CI 1.40-1.95)
Original publication
Associations of microvascular complications with all‐cause death in patients with diabetes and COVID ‐19: The CORONADO , ABCD COVID‐19 UK national audit and AMERICADO study groups. Diabetes Obes Metab. Published 12 September 2022. doi:10.
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