Risk Stratification by eGFR < 45 mL /min/1.73 m 2 for All‐Cause Mortality in Patients With Diabetic Foot Ulcer: A Multidisciplinary Retrospective Cohort Study
Authors' conclusion
DFU patients with eGFR < 45 mL/min/1.73 m2 face substantially higher long-term all-cause mortality.
Study context
- Population
- Hospitalized diabetic foot ulcer (DFU) patients in a multidisciplinary-managed cohorthospitalized DFU
- Participants
- 595 patients
- Exposure
- eGFR categories
- Outcome
- All-cause mortality
Methodological detailsmultidisciplinary-managed
- Multidisciplinary-managed
Main finding
As reported in the abstract
Each group vs eGFR ≥ 60Adjusted hazard ratio (95% CI)P value
eGFR 30-< 45
2.59(1.34–4.98)
P = 0.004eGFR < 30
4.67(2.63–8.30)
P < 0.001- Significant nonlinear eGFR-mortality relationship
- P for nonlinearity < 0.001
- Survival worsened markedly with eGFR < 45 mL/min/1.73 m²
- log-rank p < 0.001
Observational data: associations, not effects.
Further findings
Independent predictors of mortality
- Advanced age, lower BMI and reduced serum albumin independently predicted mortality
Sensitivity and subgroup analyses
- Sensitivity analyses confirmed robustness; minimal heterogeneity apart from sex-related effect modification
Original publication
Risk Stratification by eGFR < 45 mL /min/1.73 m 2 for All‐Cause Mortality in Patients With Diabetic Foot Ulcer: A Multidisciplinary Retrospective Cohort Study. Diabetes Obes Metab. Published 27 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →