Diabetes duration and advanced diabetes-related complications in lower-extremity vs coronary revascularization
Authors' conclusion
Patients undergoing revascularization for LEAD exhibited a longer diabetes duration than those undergoing revascularization for CAD. They also had a higher prevalence of advanced diabetes-related complications, even after adjustment for diabetes duration.
Study context
- Population
- Patients with diabetes undergoing revascularization for lower extremity artery disease (LEAD) or coronary artery disease (CAD), registered in a prospective multicenter study
- Participants
- 5,808 patients
- Exposure
- Revascularization for LEAD vs for CAD
- Outcome
- Diabetes-related burden: diabetes duration, HbA1c and advanced diabetes-related complications
- Follow-up
- At index revascularization
Methodological detailsregistered in a prospective multicenter study
- Registered in a prospective multicenter study
Main finding
As reported in the abstract
- LEAD had a longer diabetes duration and a higher prevalence of advanced complications than CAD
- HbA1c at revascularization did not significantly differ between the groups
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted prevalence ratio | P value | |
|---|---|---|---|
| Proliferative retinopathy, adjusted for diabetes duration | 1.57 (95% CI 1.41–1.75) | P < 0.001 | |
| Loss of protective sensation, adjusted for diabetes duration | 2.39 (CI 1.82–3.13) | P < 0.001 | |
| Dialysis-dependent renal failure, adjusted for diabetes duration | 2.12 (CI 1.82–3.13) | P < 0.001 | |
| 0.20.5125Adjusted prevalence ratio (log scale) |
- Dialysis-dependent renal failure, adjusted for diabetes duration: CI printed identical to that for loss of protective sensation
Original publication
Diabetes duration and advanced diabetes-related complications in lower-extremity vs coronary revascularization. J Clin Endocrinol Metab. Published 25 September 2026. doi:10.
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