Regulation of the Function of T Follicular Helper Cells and B Cells in Type 1 Diabetes Mellitus by the OX40/OX40L Axis
Authors' conclusion
The peripheral Tfh cells proportion increased and the OX40 expression in peripheral Tfh cells was upregulated in patients with T1DM vs patients with T2DM. OX40/OX40L signaling enhanced the Tfh-cell function to assist B-cell differentiation, which may contribute to the pathogenesis of T1DM.
Study context
- Population
- Patients with T1D or newly diagnosed T2D, endocrinology department of a university hospital, January–December 2021; 39 males, 21 females; mean age 31.0 ± 4.5 years (range 19–46)
- Participants
- 25 vs 35
- Exposure
- T1D vs newly diagnosed T2D
- T1DMn = 25
- T2DMn = 35reference
- Outcome
- OX40 expression on Tfh cells and OX40L on antigen-presenting cells (APCs) in peripheral blood, and role of OX40 signaling in Tfh-cell help for B-cell differentiation
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- T follicular helper (Tfh) cell ratio and intracellular IL-21 expression in peripheral blood significantly higher in T1DM than T2DM
- OX40 expression in peripheral Tfh cells and OX40L expression in APC significantly higher in T1DM
- After adding OX40L protein, CD19-CD138+ plasmacyte percentage significantly increased and higher in T1DM
- Blocking with anti-OX40L monoclonal antibodies significantly reduced the plasmacyte ratio
Observational data: associations, not effects.
Original publication
Regulation of the Function of T Follicular Helper Cells and B Cells in Type 1 Diabetes Mellitus by the OX40/OX40L Axis. J Clin Endocrinol Metab. Published 16 April 2024. doi:10.
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