Metabolic dysfunction-associated steatotic liver disease is associated with vascular dysfunction in type 1 diabetes
Authors' conclusion
cfPWV is the most robust vascular marker associated with MASLD in people with T1D. cfPWV, CIMT and FIB-4 correlated strongly to incident 5-year ASCVD risk. Sven Francque, Hilde Heuten and Christophe De Block have claimed equal senior authorship.
Study context
- Population
- Non-smoking adults with T1D without atherosclerotic cardiovascular disease (ASCVD); mean age 51.7 ± 15.7 years, diabetes duration 29.9 ± 14.3 years, 50% male, mean HbA1c 55.1 ± 9.5 mmol/mol (7.2 ± 0.9%)30 with MASLD
- Participants
- 105 adults
- Exposure
- MASLD vs no MASLD
- MASLDn = 30
- Outcome
- Correlation between vasculopathy (cfPWV, CIMT, FMD, NID) and MASLD
Methodological detailscase-control matched for age and diabetes duration, 2:1 control-to-case ratio
- Case-control matched for age and diabetes duration
- 2:1 control-to-case ratio
Main finding
As reported in the abstract
NID
P = 0.003
Observational data: associations, not effects.
Further findings
Impaired NID
P = 0.018
Impaired cfPWV
P = 0.043
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Increased cfPWV (adjusted multivariable logistic regression)Age, sex and mean arterial pressure also associated | 8.30 (1.25–55.2) | P = 0.029 | |
| 0.050.21520Odds ratio (log scale) |
Correlation with 5-year ASCVD risk
- cfPWV ρ (p < 0.001)
- 0.76
- CIMT ρ (p < 0.001)
- 0.81
- FIB-4 ρ (p < 0.001)
- 0.74
AUROC to identify significant ASCVD risk
- CIMT AUROC
- 0.93
- cfPWV AUROC
- 0.88
- FIB-4 AUROC
- 0.88
Original publication
Metabolic dysfunction-associated steatotic liver disease is associated with vascular dysfunction in type 1 diabetes. Cardiovasc Diabetol. Published 25 February 2026. doi:10.
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