Association between continuous glucose monitoring metrics and metabolic dysfunction-associated steatotic liver disease in adults with type 1 diabetes undergoing vibration-controlled transient elastography: a multicenter cross-sectional study
Authors' conclusion
TAR1 was independently associated with increased CAP values, even after adjustment for age, BMI, sex, HbA1c, and total daily insulin dose, suggesting a potential role for glycemic variability in hepatic fat accumulation in adults with T1D.
Study context
- Population
- Adults with established T1D undergoing vibration-controlled transient elastography (VCTE) with liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), all with continuous glucose monitoring (CGM); mean age 54±13 years, mean body mass index (BMI) 25.8 ± 5.6 kg/m², mean HbA1c 7.7 ± 1.4 %
- Participants
- 262 adults
- Outcome
- Association between CGM-derived glycemic metrics and MASLD (CAP ≥248 dB/m plus ≥1 cardiometabolic risk factor) / CAP values
Methodological detailsmulticenter, consecutive enrolment
- Multicenter
- Consecutive enrolment
Main finding
As reported in the abstract
Association of TAR1 (time above range 180-250 mg/dl) with CAP
TAR1 associated with increased CAP values
quantile regression coefficient 1.037 (95% CI [0.216;1.858])
P = 0.013
Observational data: associations, not effects.
Further findings
Prevalence of MASLD
- MASLD prevalence (n = 92)
- 35.1 %
Prevalence of significant liver fibrosis (LSM ≥8 kPa)
- Significant liver fibrosis prevalence (n = 12)
- 4.6 %
Variable importance for CAP (random forest regression)
- BMI most important factor, followed by age, total daily insulin dose and TAR1
Original publication
Association between continuous glucose monitoring metrics and metabolic dysfunction-associated steatotic liver disease in adults with type 1 diabetes undergoing vibration-controlled transient elastography: a multicenter cross-sectional study. Diabetes Metab. Published 5 July 2025. doi:10.
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