Lipids & metabolic liver disease
Low levels of osteocalcin, but not CTX or P1NP, are associated with nonalcoholic hepatic steatosis and steatohepatitis
Main finding · CTX and P1NP notResult — go to the resultOdds ratio 0.755 95% CI 0.668–0.855Authors' conclusion
Low level of osteocalcin, but not CTX or P1NP, was associated with NAFLD and NASH, indicating its potential role as an important endocrine regulator of hepatic energy metabolism.
Study context
- Population
- Cohort 1: participants without nonalcoholic fatty liver disease (NAFLD) followed for incident NAFLD by US; cohort 2: subjects undergoing liver biopsy, grouped as non-NAFLD, non-NASH or NASH (NASH Clinical Research Network)370 + 562 in two cohorts
- Exposure
- Bone turnover markers in relation to NAFLD and NASH
- Outcome
- Incident NAFLD (US) in relation to baseline bone turnover markers
- Follow-up
- Median 26.4 months
Methodological detailstwo cohorts, retrospective, liver biopsy cohort
- Two cohorts
- Retrospective
- Liver biopsy cohort
Main finding
CTX and P1NP not · median 26.4 months
Odds ratio
0.755
95% CI 0.668–0.855
P < 0.001
Osteocalcin
OR 0.755 (95% CI 0.668–0.855); P < 0.001
As reported in the abstract
- Baseline osteocalcin significantly lower in subjects who developed NAFLD (median [IQR])
- 13.93 [11.03;16.39] versus 18.24 [15.45;22.47] ng/ml, P < 0.001
Observational data: associations, not effects.
Further findings
Osteocalcin in biopsy cohort — NASH vs Non-NASH and non-NAFLD · lower with NASH
all P < 0.001
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Low osteocalcin as risk factor for NASHHighest osteocalcin quartilevs Lowest quartile | 0.282 (0.147–0.543) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Osteocalcin and degree of liver steatosis
- Osteocalcin negatively associated with degree of liver steatosis
Original publication
Low levels of osteocalcin, but not CTX or P1NP, are associated with nonalcoholic hepatic steatosis and steatohepatitis. Diabetes Metab. Published 22 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →