Lipids & metabolic liver disease
A Meta-analysis on Associated Risk of Mortality in Nonalcoholic Fatty Liver Disease
Authors' conclusion
NAFLD was associated with an increased risk of all-cause, CVD-related, and cancer-related mortality but not liver-related mortality. The finding is likely because of low fibrosis prevalence in the community. However, the significant burden in other causes of mortality beyond the liver points to a need for multidisciplinary efforts to reduce the mortality risks.
Study context
- Population
- Studies of mortality in individuals with vs without nonalcoholic fatty liver disease (NAFLD) (MEDLINE and Embase)
- Participants
- 10,286,490 participants15 studies
- Comparison
- NAFLD vs non-NAFLD
- Outcome
- All-cause, cardiovascular disease (CVD)-related, liver-related and cancer-related mortality
Methodological detailsDerSimonian and Laird random-effects model, adjusted HRs, sensitivity analysis
- DerSimonian and Laird random-effects model
- Adjusted HRs
- Sensitivity analysis
Pooled result
As reported in the abstract
Mortality
NAFLD vs Non-NAFLDEstimate (95% CI)P value
I2 = 96.00%
HR (all-cause mortality) 1.32(1.09–1.59)
P < 0.01I2 = 81.00%
HR (CVD-related mortality) 1.22(1.06–1.41)
P < 0.01I2 = 95.00%
HR (cancer-related mortality) 1.67(1.15–2.41)
P < 0.01I2 = 96.00%; not significant
HR (liver-related mortality) 3.58(0.69–18.46)
P = 0.13Further pooled results
Sensitivity analysis (heterogeneity display; population-based studies only)
- Similar results
Original publication
A Meta-analysis on Associated Risk of Mortality in Nonalcoholic Fatty Liver Disease. Endocr Pract. Published 20 October 2022. doi:10.
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