Nonalcoholic Fatty Liver Disease Is Associated With Decreased Bone Mineral Density in Adults: A Systematic Review and Meta‐Analysis
Pooled result · BMDResult — go to the resultMean difference −0.019 g/cm² 95% CI −0.036 to −0.002Authors' conclusion
Overall, our results suggest that NAFLD is associated with decreased BMD and an increased risk of osteoporosis or osteoporotic fractures.
Study context
- Population
- Adults; observational studies reporting adjusted effect sizes of nonalcoholic fatty liver disease (NAFLD) on bone mineral density (BMD), osteopenia/osteoporosis and osteoporotic fracture (searched to January 2023)19 studies
- Comparison
- NAFLD vs no NAFLD
- Outcome
- BMD and risk of osteoporosis and osteoporotic fracture
Methodological detailsmultilevel and random-effects models, adjusted effect sizes, Publication bias low; considerable heterogeneity among studies
- Multilevel and random-effects models
- Adjusted effect sizes
- Publication bias low; considerable heterogeneity among studies
Pooled result
BMD
Mean difference
−0.019 g/cm²
95% CI −0.036 to −0.002
NAFLDvs No NAFLD
mean difference −0.019 g/cm² (95% CI −0.036 to −0.002)
As reported in the abstract
Further pooled results
| Outcome | Adjusted RR (95% CI) | |
|---|---|---|
| Osteoporosis6 studies, 133,319 participants; I2 = 84% | 1.28 (1.08–1.52) | |
| Osteoporotic fracture5 studies, 227,901 participants; I2 = 67% | 1.17 (1.00–1.37) | |
| 0.512Adjusted relative risk (log scale) |
BMD by subgroup
- NAFLD had a significantly detrimental effect on BMD in men and on femoral neck and total hip BMD
Non-Asian populations
- NAFLD not associated with BMD, osteoporosis or osteoporotic fracture in non-Asian populations
Original publication
Nonalcoholic Fatty Liver Disease Is Associated With Decreased Bone Mineral Density in Adults: A Systematic Review and Meta‐Analysis. J Bone Miner Res. Published 12 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →