Lipids & metabolic liver disease
Nonalcoholic Fatty Liver Disease and Adverse Pregnancy Outcomes in Women With Normal Prepregnant Weight
Authors' conclusion
Women with NAFLD and a normal weight have a higher risk for adverse pregnancy outcomes. Pregnant women with NAFLD, regardless of obesity status, should be offered a more qualified surveillance to optimize pregnancy outcomes.
Study context
- Population
- Pregnant women delivering at Minhang Hospital, Fudan University, Shanghai, China, 2013–2020; mean prepregnant body mass index (BMI) 21.0 (SD 2.8) kg/m²
- Participants
- 14,708 women
- Exposure
- Nonalcoholic fatty liver disease (NAFLD) vs no NAFLD
- NAFLDn = 554
- Outcome
- Adverse pregnancy outcomes
Methodological detailssingle-centre, logistic regression adjusted for confounders
- Single-centre
- Logistic regression adjusted for confounders
Main finding
As reported in the abstract
Adverse pregnancy outcomes (fully adjusted)
Each group vs no NAFLDEstimate (95% CI)
NAFLD
aOR, GDM 2.477(1.885–3.254)
NAFLD
aOR, gestational hypertension 3.054(2.191–4.257)
NAFLD
aOR, preeclampsia/eclampsia 3.994(2.591–6.005)
NAFLD
aOR, cesarean section 1.569(1.315–1.872)
NAFLD
aOR, preterm birth 1.831(1.229–2.727)
NAFLD
aOR, macrosomia 1.691(1.300–2.198)
Observational data: associations, not effects.
Further findings
Normal prepregnant weight subgroup (18.5 ≤ BMI < 24 kg/m²)
- Women of normal weight at start of pregnancy
- 83.9% (12 338)
- Normal-weight women with NAFLD still had higher odds of adverse pregnancy outcomes
Original publication
Nonalcoholic Fatty Liver Disease and Adverse Pregnancy Outcomes in Women With Normal Prepregnant Weight. J Clin Endocrinol Metab. Published 1 October 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →