Lipids & metabolic liver disease
Association of serum uric acid with all‐cause and cardiovascular mortality among adults with nonalcoholic fatty liver disease
Authors' conclusion
In a large and nationally representative sample of US adults, a higher SUA was significantly associated with a higher risk of CVD mortality among participants with NAFLD, but not in those without NAFLD.
Study context
- Population
- US adults, National Health and Nutrition Examination Survey (NHANES) 1999–2014; mortality from National Death Index until 2015
- Participants
- 17,858 adults
- Exposure
- Higher vs lower serum uric acid (SUA), in adults with vs without nonalcoholic fatty liver disease (NAFLD)
- NAFLDn = 5,767
- Outcome
- CVD mortality
- Follow-up
- Mean 8.3 years
Methodological detailsnationally representative, NHANES 1999-2014
- Nationally representative
- NHANES 1999-2014
Main finding
As reported in the abstract
CVD mortality per SD μmol/L SUA increment
Adjusted hazard ratio (95% CI)
NAFLD: per SD μmol/L SUA increment
1.40(1.16–1.68)
Without NAFLD: per SD μmol/L SUA increment
1.01(0.83–1.22)
Per SD μmol/L SUA increment, as printed
- Participants who died from CVD
- 427
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| CVD mortality in NAFLD, SUA fourthvs first quartileParticipants with NAFLD | 2.69 (1.51–4.80) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
All-cause mortality
- Similar trends were found for all-cause mortality
Sensitivity analysis: NAFLD defined by FLI ≥ 60
- Similar results when using FLI ≥ 60 to define NAFLD
Original publication
Association of serum uric acid with all‐cause and cardiovascular mortality among adults with nonalcoholic fatty liver disease. Clin Endocrinol (Oxf). Published 22 August 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →