Lipids & metabolic liver disease
Baseline and change in serum uric acid level over time and resolution of nonalcoholic fatty liver disease in young adults: The Kangbuk Samsung Health Study
Authors' conclusion
Low baseline SUA levels and a decrease in SUA levels over time were both associated with NAFLD resolution in young adults.
Study context
- Population
- Adults aged <40 years with pre-existing nonalcoholic fatty liver disease (NAFLD), health examination 2011–2019 with ≥1 follow-up liver US up to December 2020 (Kangbuk Samsung Health Study)25,266 for serum uric acid (SUA) change
- Participants
- 38,483 adults
- Exposure
- Quintiles of baseline SUA and of SUA change over time; Q3 as reference
- Outcome
- Resolution of NAFLD
- Follow-up
- Median 4 years
Methodological detailstime-dependent model with SUA change as time-varying covariate
- Time-dependent model with SUA change as time-varying covariate
Main finding
As reported in the abstract
NAFLD resolution by SUA change quintile (time-dependent model, SUA change as time-varying covariate)
AHR for NAFLD resolution (95% CI)
Q1 (highest decrease), menvs Q3 (reference), men
1.63(1.49–1.78)
Q2 (slight decrease), menvs Q3 (reference), men
1.23(1.11–1.35)
Q1 (highest decrease), womenvs Q3 (reference), women
1.78(1.49–2.12)
Q2 (slight decrease), womenvs Q3 (reference), women
1.18(0.95–1.46)
- Low baseline SUA and decreases in SUA over time independently associated with NAFLD resolution
- P for trend < 0.001
Observational data: associations, not effects.
Further findings
NAFLD resolution per 1-mg/dL decrease in SUA (continuous)
- Increase in likelihood of resolution, men
- 10%
- Increase in likelihood of resolution, women
- 13%
Original publication
Baseline and change in serum uric acid level over time and resolution of nonalcoholic fatty liver disease in young adults: The Kangbuk Samsung Health Study. Diabetes Obes Metab. Published 1 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →