Lipids & metabolic liver disease
Physical activity intensity and markers of inflammation in those with non-alcoholic fatty liver disease
Authors' conclusion
LPA does not appear to be effective at improving homocysteine or CRP levels in individuals with NAFLD. However, MVPA may be an effective therapy for decreasing CRP in NAFLD patients.
Study context
- Population
- Individuals with Non-Alcoholic Fatty Liver Disease (NAFLD), National Health and Nutrition Examination Survey 2003–2006
- Participants
- 983 individuals
- Exposure
- Tertiles of average daily minutes of LPA or MVPA
- Outcome
- Plasma homocysteine and serum C-reactive protein (CRP) across tertiles of LPA and MVPA
Methodological detailssecondary analysis of NHANES 2003–2006 data, accelerometer-measured physical activity
- Secondary analysis of NHANES 2003–2006 data
- Accelerometer-measured physical activity
Main finding
As reported in the abstract
Adjusted CRP across MVPA tertiles
1st tertile
0.87
± 0.13 · mg/dL
2nd tertile
0.75
± 0.10 · mg/dL
3rd tertile
0.65
± 0.09
P = 0.02
Observational data: associations, not effects.
Further findings
Adjusted plasma homocysteine across LPA tertiles — between 1st tertile and 3rd tertile · not different across LPA tertiles · adjusted
P = 0.28
Adjusted CRP across LPA tertiles — between 1st tertile and 3rd tertile · not different across LPA tertiles · adjusted
P = 0.72
Original publication
Physical activity intensity and markers of inflammation in those with non-alcoholic fatty liver disease. Diabetes Res Clin Pract. Published 7 December 2023. doi:10.
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