Lipids & metabolic liver disease
Follistatin‐like 1 is a myokine regulating lipid mobilization during endurance exercise and recovery
Authors' conclusion
Fstl1 is a myokine facilitating lipid mobilization during and after endurance exercise through DIP2a-mediated lipolytic effects in adipocytes.
Study context
- Population
- Sedentary males undergoing endurance exercise
- Participants
- 29 sedentary males
Methodological detailshuman endurance exercise study, 3T3-L1 adipocyte experiments with DIP2a knockdown
- Human endurance exercise study
- 3T3-L1 adipocyte experiments with DIP2a knockdown
Main finding
As reported in the abstract
- Fstl1 levels significantly increased during endurance exercise and following recovery, correlating with lean body mass and lipolysis
- In 3T3-L1 adipocytes, Fstl1 increased glycerol release, cyclic GMP production and hormone sensitive lipase activation; effects attenuated by DIP2a knockdown
- DIP2a gene expression in human adipose tissues correlated with serum glycerol during endurance exercise
Original publication
Follistatin‐like 1 is a myokine regulating lipid mobilization during endurance exercise and recovery. Obesity (Silver Spring). Published 29 November 2023. doi:10.
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