Lipids & metabolic liver disease
Temporal relationship between triglyceride-glucose index and blood pressure and their joint cumulative effect on cardiovascular disease risk: a longitudinal cohort study
Authors' conclusion
These findings suggest that elevated TyG has a greater impact on future blood pressure changes than vice versa. Dual assessment and management of insulin resistance and blood pressure contribute to the prevention of CVD, especially in younger individuals.
Study context
- Population
- Participants of the Kailuan Study; Cardiovascular disease (CVD) outcome analysis in nonCVD participants without known diabetes; exposure period 2006/2007 to 2010/201156,313 in CVD analysis
- Participants
- 57,192 participants
- Exposure
- Cumulative TyG and blood pressure (BP) co-exposure categories vs cumulative TyG (CumTyG) < 8.61 and CumSBP < 130 mmHg
- Outcome
- Incident CVD
- Follow-up
- Median 9.98 years
Methodological detailslongitudinal, cross-lagged analysis, real-world
- Longitudinal
- Cross-lagged analysis
- Real-world
Main finding
As reported in the abstract
- CVD cases
- 3981
- Adjusted hazard ratios (HRs) (95% confidence intervals (CIs)) for Q2-Q6 vs CumTyG < 8.61 and CumSBP < 130 mmHg; HR gradually increased in the high co-exposure groups
- 1.39 (1.24, 1.57), 1.94 (1.69, 2.22), 2.40 (2.12, 2.71), 2.74 (2.43, 3.10), and 3.07 (2.74, 3.45)
- Interaction median CumTyG (8.61) × CumSBP thresholds (130, 140 mmHg)
- P = 0.0149
- Interaction median CumTyG (8.61) × CumDBP thresholds (80, 90 mmHg)
- P = 0.0441
Observational data: associations, not effects.
Further findings
Cross-lagged association TyG and systolic BP · ≈4-year exposure period
- Standard regression coefficient baseline TyG → follow-up SBP
- 0.0142 (95% CI 0.0059-0.0226)
- Standard regression coefficient baseline SBP → follow-up TyG (95% CI - 0.0469 to - 0.0311)
- - 0.0390
Cross-lagged association TyG and diastolic BP · ≈4-year exposure period
- TyG → DBP (0.0185 to 0.0356)
- 0.0271
- DBP → TyG (- 0.0451 to - 0.0293)
- - 0.0372
CVD risk of co-exposure by age
- CVD risks in the co-exposure more prominent in younger participants
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Temporal relationship between triglyceride-glucose index and blood pressure and their joint cumulative effect on cardiovascular disease risk: a longitudinal cohort study. Cardiovasc Diabetol. Published 28 November 2023. doi:10.
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