Lipids & metabolic liver disease
Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (cardiovascular-kidney-metabolic (CKM)) stages 0–3: a nationwide prospective cohort study
Authors' conclusion
Higher two-visit cumulative TyG-nTLP burden was associated with incident CVD after accounting for competing death. However, incremental discrimination was small, and shared laboratory components limit claims of biological independence or synergy.
Study context
- Population
- Adults with CKM stages 0–3 and valid post-landmark CVD follow-up, China Health and Retirement Longitudinal Study827 developed CVD
- Participants
- 4,420 adults
- Exposure
- Cumulative dual-high vs dual-low triglyceride-glucose (TyG)-nTLP exposure
- Outcome
- Incident CVD; five cumulative dual-high vs dual-low comparisons (TyG with atherogenic index of plasma (AIP), non-HDL-C, CRI-I, CRI-II, lipoprotein combine index (LCI))
Methodological detailsnationwide, landmark analysis, cause-specific Cox and Fine-Gray models, Benjamini-Hochberg correction
- Nationwide
- Landmark analysis
- Cause-specific Cox and Fine-Gray models
- Benjamini-Hochberg correction
Main finding
As reported in the abstract
Incident CVD, cumulative dual-high vs dual-low
Estimate (95% CI)
Dual-highvs Dual-low
adjusted Cox HR (range across 5 comparisons, lowest) 1.29(1.09–1.52)
Dual-highvs Dual-low
adjusted Cox HR (range across 5 comparisons, highest) 1.45(1.20–1.74)
Dual-highvs Dual-low
Fine-Gray SHR (range, lowest) 1.28(1.09–1.50)
Dual-highvs Dual-low
Fine-Gray SHR (range, highest) 1.43(1.19–1.72)
- All primary FDR q values
- < 0.003
Observational data: associations, not effects.
Further findings
Stroke
- Stroke events (n = 4414)
- 328
- Secondary stroke estimates were generally larger
Heart disease
- Heart-disease events (n = 4,411)
- 571
Five-year prediction: covariate-only model
- C-index
- 0.616
- IPCW AUC
- 0.634 (95% CI 0.608-0.659)
Five-year prediction: best expanded model (TyG plus CRI-II)
- C-index
- 0.628
- AUC (0.640-0.690)
- 0.665
- Change in C-index
- 0.012
- Change in AUC
- 0.031
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Antecedent, landmark, and two-visit cumulative triglyceride-glucose index and non-traditional lipid measures in relation to incident cardiovascular disease in adults with cardiovascular-kidney-metabolic syndrome (CKM) stages 0–3: a nationwide prospective cohort study. Cardiovasc Diabetol. Published 23 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →